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Tibolone

Tibolone

Tibolone is a synthetic analog of the gonadal steroids with combined estrogenic, progestogenic and androgenic properties. Its effects on BMD are comparable to those of hormone replacement therapy.. Although The Long term Intervention on Fractures with Tibolone (LIFT) study indicates beneficial effects of tibolone on vertebral fracture risk in postmenopausal women (HR=0.59), this study has been stopped owing to an increased risk of strokes(HR=2.3, after 2.75 years) (ischaemic plus haemorraigic).

Reference

  1. Cummings SR. LIFT study is discontinued. BMJ 2006;332:667
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