FRAX® - Information and Resources
General Information about FRAX®
IOF FRAX® Slide-kit /educational tool
Publications and references
General Information about FRAX®
The launch of the World Health Organization (WHO) technical report, Assessment of osteoporosis at the primary health care level1 and the related FRAX® tool are major milestones towards helping health professionals worldwide to improve identification of patients at high risk of fracture. The practical web-based tool, FRAX® , assesses the ten-year risk of osteoporosis fracture in men and women. It is of considerable use to health care professionals and policy makers throughout the world, particularly in places where there are few DXA machines. An individual’s risk factors such as age, sex, weight, height, and femoral neck BMD if available, are entered into the website tool, followed by clinical risk factors which include a prior fragility fracture, parental history of hip fracture, current tobacco smoking, long-term use of glucocorticoids, rheumatoid arthritis, other causes of secondary osteoporosis and daily alcohol consumption. The FRAX® tool then provides a figure indicating a ten-year fracture probability as a percentage, which, together with a clinical assessment, provides guidance for determining access to treatment in healthcare systems.
To access the calculation tool and for further information:
Visit the FRAX® website
IOF FRAX® Slide-kit /educational tool
Letter of introduction (PDF, 121.2 KB)
IOF FRAX® Instructions (PDF, 123.8 KB)
IOF FRAX® Slides (PPT, 11.13 MB)
IOF FRAX® Slide annotations (PDF, 2.84 MB)
Reference list for further reading (PDF, 131.1 KB)
Please note that the Slide-kit may only be used for educational presentations and non commercial purposes.
Please take a moment to give us your feedback by filling in the IOF FRAX® survey. The survey consists of only four questions. If you have any further comments, please contact us.
Publications and references:
Below is a listing of reviews and summary reports (with links for download where available) as well as several of the references to the educational slide kit. Complete references to the slide kit are available in the PDF above. Visit the FRAX website at http://www.shef.ac.uk/FRAX/reference.htm for an updated list of background reading and other references.
Reviews:
1. WHO Scientific Group Technical Report
Kanis JA, on behalf of the World Health Organisation Scientific Group. Assessment of osteoporosis at the primary health care level. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield 2008. Assessment of osteoporosis at the primary health care level (slide12)
[Available on request from the WHO Collaborating Centre or the IOF -
quantities limited]
2. World Health Organisation Scientific Group on the assessment of osteoporosis at the primary health care level. Summary Meeting Report. World Organisation 2007. May be downloaded from www.who.int/chp/topics/rheumatic/en/index.html
3. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002: 359; 1929-1936.
4. Kanis JA, Black D, Cooper C, Dargent P, Dawson-Hughes B, De Laet C, Delmas P, Eisman J, Johnell O, Jonsson B, Melton LJ, Oden A, Papapoulos S, Pols H, Rizzoli R, Silman A, Tenenhouse A on behalf of the International Osteoporosis Foundation and the National Osteoporosis Foundation, USA. A new approach to the development of assessment guidelines for osteoporosis. Osteoporosis International 2002: 13; 527-536.
5. Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, Oden A, Zethraeus N, Pfleger B, Khaltaev N. Assessment of fracture risk. Osteoporosis International 2005; 16: 581-589. (slide 6)
Guidelines incorporating FRAX® :
Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster, JY, Borgström F, Rizzoli R, on behalf of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women (PDF, 531.6 KB). Osteoporos Int (2008) 19:399-428.
Osteoporosis - Clinical guideline for prevention and treatment (UK)
National Osteoporosis Guideline Group (NOGG) on behalf of the Bone Research Society, British Geriatrics Society, British Orthopaedic Association, British Society of Rheumatology, National Osteoporosis Society, Osteoporosis 2000, Osteoporosis Dorset, Primary Care Rheumatology Society, Royal College of Physicians and Society for Endocrinology
Click here to view or download)
The National Osteoporosis Foundation (NOF) Clinician's Guide to prevention and treatment of osteoporosis 2008. National Osteoporosis Foundation, Washington, DC.
Website: http://www.nof.org/professionals/NOF_Clinicians_Guide.pdf
More reading: (please visit the FRAX website for complete references and backgroung reading)
Assessment of 10-year absolute fracture risk: a new paradigm with worldwide application. (PDF, 52.7 KB) Siris E and Delmas PD. Osteoporos Int (2008) 19:383-384
FRAX™ and the assessment of fracture probability in men and women from the UK (PDF, 368.6 KB)
Kanis JA, Johnell O, Oden A, Johansson H and McCloskey E.
Osteoporos Int (2008) 19:385-397 (slides 7,10,11)
Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX™) (PDF, 229.2 KB)
Fujiwara S, Nakamura T, Orimo H, Hosoi T, Gorai I, Oden A, Johansson H and Kanis JA. Osteoporos Int (2008) 19:429-435
Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA
Dawson-Hughes B, Tosteson ANA, Melton LJ, Baim S, Favus MJ, Khosla S and Lindsay RL. Osteoporos Int (2008) 19: 449-458
