IOF Positions and Statements

A new study by an International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) scientific working group summarizes the clinical performance of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cross-linking telopeptide of type I collagen (s-CTX) in fracture risk prediction in untreated individuals in prospective... Read more
One of the most important advances in osteoporosis management of the past decade has been the advent of fracture risk assessment algorithms. Today, rather than relying on bone mineral density values alone, doctors use tools such as FRAX, a widely available calculator (, to help identify patients in need of treatment. Read more
This statement is in response to a recent report published in the Lancet which has implied that vitamin D does not prevent osteoporosis, defined as low bone mineral density (BMD), in healthy middle-aged people (1). The authors found that vitamin D had no net effect on BMD at the spine but that it did significantly increase femoral neck BMD. Read more
A new systematic review published in the British Journal of Nutrition*, is one of the first to focus on patterns of vitamin D status worldwide and in key population subgroups, using continuous values for 25(OH)D to improve comparisons. Read more
Distal radius fractures (often simply termed wrist or Colles' fractures) are the second most common fractures in the elderly. Beyond the immediate impact on the patient, wrist fractures in older adults often indicate underlying osteoporosis and high risk of subsequent fragility fractures. Read more
The International Osteoporosis Foundation (IOF) has endorsed a global consensus statement on menopausal hormone therapy (MHT) published today in the journals Climacteric and Maturitas. Read more
The International Osteoporosis Foundation (IOF) concurs with the United States Preventive Services Task Force (USPSTF)1 which has stated that daily supplementation with doses of vitamin D ≤ 400 IU and calcium ≤ 1,000 mg has no net benefit for the primary prevention of fractures in non-institutionalized asymptomatic adults without previous history of fractures. Read more
Sarcopenia, or the gradual loss of muscle mass, is a common consequence of ageing, and poses a significant risk factor for disability in older adults. As muscle strength plays an important role in the tendency to fall, sarcopenia leads to an increased risk of fractures and other injuries. Read more
Much of the research defining osteoporosis and fracture risk has focused on older adults, i.e. postmenopausal women and men over the age of 50. While older adults areat highest risk of osteoporosis and related fractures, the disease can also affect younger adultsbetween 20 and 50 years of age. Read more
A solid body of evidence shows that calcium is an important mineral for bone health in people of all ages. In early life, calcium helps to build stronger and denser bones. In later life, it plays a critical role in reducing the risk for osteoporosis and fractures. Read more


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