Bone Turnover Markers Educational Course

Bone Turnover Markers (BTM) have been extensively used in clinical research to monitor the efficacy and mechanisms of action of new drugs. These markers, measured in serum or urine, assess alterations in skeletal metabolism (regardless of the underlying cause).  However, in contrast to their extensive use in research, there are uncertainties in their use for routine clinical application. Potentially, BTMs could play an important role in the identification of individuals who would best benefit from intervention and, for those on treatment, in the optimization of the monitoring of response to treatment.

This 52-slide educational course includes comprehensive information on the following:

  • Classification of BTMs
  • Attractiveness and limitations of BTMS
  • Uncontrollable and controllable sources of pre-analytical variability
  • Seasonal and diurnal variation
  • BTMs and BMD
  • BTMs and fracture risk
  • Relationship between bone turnover and bone loss
  • BTM responses to various therapies and routes of administration
  • Changes in BTM after treatment
  • BTM and BMD monitoring
  • Reference intervals
  • Drug holidays
  • Potential role of BTMS
  • IOF-IFCC Recommendations for international reference standards

Slide kit (PPT)
Slide kit as PDF, with comments for presenter’s use.

Related information:
Read about the IOF-IFCC Bone Marker Standards Working Group
and the position paper:
Vasikaran S, Eastell R, Bruyere O, Foldes AJ, Garnero P, Griesmacher A, McClung M, Morris HA, Silverman S, Trenti T, Wahl DA, Cooper C, Kanis JA; IOF-IFCC Bone Marker Standards Working Group. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards Osteoporos Int 2011;22(2):391-420.