Epidemiology/Quality of Life Working Group


Chairs: JA Kanis, N Harvey
Members: B Abrahamsen, J Adachi, F Borgström, O Bruyère, J Carey, P Clark, C Cooper, E Dennison, M Diaz Curiel, HP Dimai, D Gregorie, M Hiligsmann, H Johansson, E Lau, M Lewiecki, P Lips, R Lorenc, E McCloskey, S Ortolani, A Papaioannou, D Prieto Alhambra, S Silverman, M Sosa, P Szulc, K Ward, N Yoshimura


The Epidemiology/Quality of Life Working Group establishes projects which aim to estimate the epidemiology of osteoporosis around the world, to evaluate the impact of fragility fractures on health-related quality of life and finally to measure the direct and indirect cost of osteoporotic fractures worldwide.


  1. Estimate the cost and quality of life following a hip fracture, a vertebral fracture and a wrist fracture in different countries, through the International Cost and Utilities Related to Osteoporotic fractures Study (ICUROS)
  2. Further develop the fracture risk assessment tool (FRAX®) by increasing its international scope and its use in clinical practice
  3. EU6 academic publication accompanying policy report published in October 2018
  4. Oldest old initiative: To study how treatment effectiveness and risk factors behave in the Oldest Old compared with younger populations (O Ström, F Borgström, K Åkesson, Ö Ljunggren, A Spångeus)
  5. Lifecourse: importance of addressing the risk of osteoporosis across the whole lifecourse
  6. Provide new data on the global epidemiology and impact of osteoporotic fracture worldwide
  7. Screening for fracture risk
  8. Cohort harmonisation/inventory

Managing treatment cessation - subgroup Epi/QoL

Chair: S Ferrari
Members: J Adachi, E Dennison, M Lewiecki, E McCloskey, D Prieto-Alhambra, S Silverman

  • Algorithm


To be published soon:

Dennison, E.M., et al., Fracture risk following intermission of osteoporosis therapy. Osteoporos Int.

Extensive undertreatment of osteoporosis in older Swedish women. 
Lorentzon, M., et al. Osteoporos Int, 2019.

Bisphosphonate drug holidays: we reap what we sow. 
Silverman, S.L., J.D. Adachi, and E. Dennison. Osteoporos Int, 2016. 27(3): p. 849-852.

A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation.

Kanis, J., Harvey, N., Cooper, C., Johansson, H., Odén, A. and McCloskey, E.

The Advisory Board of the National Osteoporosis Guideline Group.

Archives of Osteoporosis (2016). DOI 10.1007/s11657-016-0278-z


Quality of life, resource use, and costs related to hip fracture in Estonia.

Jürisson, M., Pisarev, H., Kanis, J. et al.

Osteoporosis International (2016). DOI 10.1007/s00198-016-3544-4


Bisphosphonate drug holidays: we reap what we sow.

Silverman, S., Adachi, J., Dennison, E. and the International Osteoporosis Foundation Epidemiology/Quality of Life Working Group.

Osteoporosis International (2015). DOI 10.1007/s00198-015-3453-y


Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS).

Abimanyi-Ochom, J., Watts, J., Borgström, F. et al.

Osteoporosis International (2015). DOI 10.1007/s00198-015-3088-z


Worldwide uptake of FRAX.

Kanis, J., Johansson, H., Oden, A., Cooper, C., McCloskey, E. and the Epidemiology and Quality of Life Working Group of IOF.

Archives of Osteoporosis (2014). DOI 10.1007/s11657-013-0166-8


Standardising the descriptive epidemiology of osteoporosis: recommendations from the Epidemiology and Quality of Life Working Group of IOF.

Kanis, J., Adachi, J., Cooper, C. et al.

Osteoporosis International (2013). DOI 10.1007/s00198-013-2413-7


The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)—quality of life during the first 4 months after fracture.

Borgström, F., Lekander, I., Ivergård, M. et al.

Osteoporosis International (2013). DOI 10.1007/s00198-012-2240-2


Economic burden of osteoporotic fractures in Austria.

Dimai, H., Redlich, K., Peretz, M., Borgström, F., Siebert, U. and Mahlich, J.

Health Economics Review (2012). DOI 10.1186/2191-1991-2-12


A systematic review of hip fracture incidence and probability of fracture worldwide.

Kanis, J., Odén, A., McCloskey, E., Johansson, H., Wahl, D. and Cooper, C. on behalf of the IOF Working Group on Epidemiology and Quality of Life.

Osteoporosis International (2012). DOI 10.1007/s00198-012-1964-3


Secular trends in the incidence of hip and other osteoporotic fractures.

Cooper, C., Cole, Z., Holroyd, C. et al. and the IOF CSA Working Group on Fracture Epidemiology.

Osteoporosis International (2011). DOI 10.1007/s00198-011-1601-6


Validation of the IOF quality of life questionnaire for patients with wrist fracture.

Lips, P., Jameson, K., Bianchi, M. et al. and the Working Group for Quality of Life of the International Osteoporosis Foundation.

Osteoporosis International (2009). DOI 10.1007/s00198-009-0946-6