IOF-IFCC Bone Marker Standards Working Group

 

Chairs: C Cooper (IOF) and H Morris (IFCC)
IOF Members: K Åkesson, O Bruyère, R Eastell, N Jorgensen, J Kanis, J Foldes, M McClung, S Silverman
IFCC Members: A Griesmacher, N Lane, T Trenti, S Vasikaran
Co-opted: P Garnero

Aim

This working group seeks to identify consensus reference standard bone resorption marker and bone formation marker for fracture risk assessment and monitoring of osteoporosis treatment. 

Objectives

  1. Identify a consensus reference standard marker for bone resorption (CTX) and for bone formation (P1NP) for fracture risk assessment and monitoring of osteoporosis treatment.
  2. Review the performance of the assays for the standard markers and recommend requirement for standardization of their measurements.
  3. Arrive at a consensus on the diagnostic cut-points and/or action limits for the bone turnover marker assays for intervention and alteration of therapy.
  4. Consult with key international organizations in order to gain international acceptance of the consensus of the WG and its implementation.
  5. Publish guidelines on the use of bone turnover marker assays for fracture risk assessment and monitoring of osteoporosis treatment.
  6. Define research questions that need answers in this area.

Publications

H.A. Morris, R. Eastell, N.R. Jorgesen, E. Cavaliere, S. Vasikaran, S.A.P. Chubb, J.A. Kanis, C. Cooper, K. Makrisi, on behalf of the IFCC-IOF Working Group for Standardisation of Bone Marker Assays (WG-BMA). Clinical usefulness of bone turnover marker concentrations in osteoporosis. Clin Chim Acta (2016) doi:10.1016/j.cca.2016.06.036

Johansson H,  Odén A, Kanis JA, McCloskey EV, Morris HA, Cooper C, Vasikaran S and the IFCC-IOF Joint Working Group on standardisation of biochemical markers of bone turnover
A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcif Tissue Int DOI 10.1007/s00223-014-9842-y

Clinical usefulness of bone turnover marker concentrations in osteoporosis. Morris HA, Eastell R, Jorgesen NR, Cavalier E, Vasikaran S, Chubb SA, Kanis JA, Cooper C, Makris K; IFCC-IOF Working Group for Standardisation of Bone Marker Assays (WG-BMA).

Clin Chim Acta. 2016 Jun 30. pii: S0009-8981(16)30281-9. doi: 10.1016/j.cca.2016.06.036. [Epub ahead of print]

Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
S. Vasikaran, R. Eastell, O. Bruyère, A. J. Foldes and P. Garnero, et al. (2011)
Osteoporos Int. 22 (2): 391-420, DOI: 10.1007/s00198-010-1501-1.

Related content: Bone Turnover Markers Educational Course

International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine Position on bone marker standards in osteoporosis
S. Vasikaran, C.Cooper, R.Eastell, A.Griesmacher, H. A. Morris, T. Trenti, J. A. Kanis (2011)
Clinical Chemistry and Laboratory Medicine. ISSN (Online) 1437-4331, DOI: 10.1515/CCLM.2011.602.

Recommendations for bone marker standards in osteoporosis: what, why and where to now?
S. D. Vasikaran, C. Cooper and J. A. Kanis

Annals of Clinical Biochemistry 2011; 48:91-92.