IOF-IFCC Bone Marker Standards Working Group



Chair: E Cavalier

IOF: K Åkesson, O Bruyère, C Cooper, R Eastell, J Foldes, P Garnero, NR Jørgensen, JA Kanis, N Lane, M McClung, S Silverman
IFCC: HP Bhattoa, V Delatour, A Griesmacher, A Heijboer, C Sempos, C Sturgeon, C Ulmer, S Vasikaran, H Vesper



This working group seeks to identify consensus reference standard markers for bone resorption and bone formation, for fracture risk assessment and monitoring of osteoporosis treatment. 


  • Harmonisation and standardisation of selected bone markers (CTX and P1NP)
  • Clinical usefulness of bone turnover marker levels


Related content: Bone Turnover Markers Educational Course

  • A multicenter study to evaluate harmonization of assays for N-terminal propeptide of type I procollagen (PINP): a report from the IFCC-IOF Joint Committee for Bone Metabolism. Cavalier, E., Eastell, R., Rye Jørgensen, N., et al. (2019).  Clinical Chemistry and Laboratory Medicine (CCLM), doi:10.1515/cclm-2019-0174 
  • Clinical usefulness of bone turnover marker concentrations in osteoporosis. Morris, H., Eastell, R., Jorgensen, N. et al. on behalf of the IFCC-IOF Working Group for Standardisation of Bone Marker Assays.Clinica Chimica Acta (2017). DOI 10.1016/j.cca.2016.06.036
  • A Meta-Analysis of Reference Markers of Bone Turnover for Prediction of Fracture. Johansson, H., Odén, A., Kanis, J. et al. and the IFCC-IOF Joint Working Group on Standardisation of Biochemical Markers of Bone Turnover. Calcified Tissue International (2014). DOI 10.1007/s00223-014-9842-y
  • International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine Position on bone marker standards in osteoporosis. Vasikaran, S., Cooper, C., Eastell, R. et al. Clinical Chemistry and Laboratory Medicine (2011). DOI 10.1515/cclm.2011.602
  • Recommendations for bone marker standards in osteoporosis: what, why and where to now? Vasikaran, S., Cooper, C. and Kanis, J. Annals of Clinical Biochemistry (2011). DOI 10.1258/acb.2011.010286
  • Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Vasikaran, S., Eastell, R., Bruyère, O. et al. for the IOF-IFCC Bone Marker Standards Working Group. Osteoporosis International (2010). DOI 10.1007/s00198-010-1501-1