Experts present new knowledge on bone tissue and its role in bone strength or weakness

bone material properties
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A collection of eight invited reviews by leading researchers provides new insights into bone material properties, the various mineral, collagen and water compartments in bone, and the role of these properties in skeletal fragility.

While there is good understanding of how bone mass, and more recently bone architecture, affects fracture risk, far less is known about the material properties of bone, or how these can impart resilience or fragility to the skeleton. This is changing thanks to the development of new state-of-the-art imaging and other technologies which now allow researchers to gain new insights into the different material properties of bone and their role in bone fragility.

Bringing together eight invited contributions by the field’s leading experts, a special issue of Calcified Tissue International & Musculoskeletal Research now provides a comprehensive overview of the latest and most exciting findings in this area of skeletal research. The issue is co-edited by Drs. David B. Burr and Matthew R. Allen of the Department of Anatomy and Cell Biology, Indiana University School of Medicine.

Drs. Burr and Allen, the co-editors, challenged the authors not only to review the current state of knowledge about their specific topic, but to help propel research forward by highlighting key questions that remain to be addressed. 

Our hope is that this will stimulate the new wave of work aimed at understanding both the hierarchical structure of bone and its importance to overall bone health.”

The 8 reviews are:

Professor René Rizzoli, Co Editor-in-Chief of Calcified Tissue International stated,

We expect that this special issue will help provide a new understanding of the role of bone as a tissue, and how it contributes to skeletal integrity. This is an emerging area of research which is expected to have significant clinical relevance in the future.”

Calcified Tissue International & Musculoskeletal Research

This peer-reviewed journal publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions. NEW 2014 Impact Factor: 3.272
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Editors in Chief: Stuart Ralston, René Rizzoli;
Musculoskeletal Research Section Editor: Roger Fielding

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