There is considerable interest in the impact of adiposity on the skeleton – driven in part by the enormous increase in the prevalence of obesity and osteoporosis. However, despite the increased volume of research on the topic, there is still much debate and conflicting evidence.
In their introduction to a dedicated special issue in Calcified Tissue Int, topic editors Paul Dimitri and Cliff Rosen state:
The ever-intriguing, complex and rapidly emerging relationships between fat and bone from a cellular to clinical level inspired us to bring together experts in the field to provide a series of commissioned reviews summarizing the latest advances. One of the greatest challenges is the translation of current knowledge into relevant clinical applications. Importantly, this special ‘fat and bone’ edition highlights areas that require further work to enhance our understanding of fat-bone relationships on a background of many other factors that influence skeletal metabolism.”
Below we list the reviews – and invite you to read, share and cite!
- Fat and Bone: Where are We Now? Paul Dimitri, Cliff Rosen
- Adipose, Bone, and Myeloma: Contributions from the Microenvironment
Michelle M. McDonald, Heather Fairfield, Carolyne Falank, Michaela R. Reagan
- Restrictive Eating Disorders and Skeletal Health in Adolescent Girls and Young Women
Darcey Thornton, Catherine M. Gordon
- Evolution of the Marrow Adipose Tissue Microenvironment
Clarissa S. Craft, Erica L. Scheller
- The Central Nervous System and Bone Metabolism: An Evolving Story
Paul Dimitri, Cliff Rosen
- The Activity of Adiponectin in Bone
Dorit Naot, David S. Musson, Jillian Cornish
- The Impact of Fat and Obesity on Bone Microarchitecture and Strength in Children
Joshua N. Farr, Paul Dimitri
- Bone Density in the Obese Child: Clinical Considerations and Diagnostic Challenges
Jennifer C. Kelley, Nicola Crabtree, Babette S. Zemel
Additional related reading:
- Obesity, Type 2 Diabetes and Bone in Adults
Jennifer S. Walsh, Tatiane Vilaca
- Comment on “Reference Values of Total Lean Mass, Appendicular Lean Mass, and Fat Mass Measured with Dual-Energy X-ray Absorptiometry in a Healthy Mexican Population”
Jose M. Moran (et. al)
The link provided allows you to read the article as a guest. If you do not have access to Calcified Tissue International via your institution, we invite you to sign up as a Professional IOF member to receive low cost online access to IOF journals.
About Calcified Tissue International & Musculoskeletal Research
Calcified Tissue International & Musculoskeletal Research is a peer-reviewed journal which publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
Editors in Chief: Stuart Ralston and René Rizzoli; Musculoskeletal Research Section Editor: Roger Fielding.